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Evaluation of Intravenous MagnesiumSupplementation as Prophylaxis forCisplatin-induced Hypomagnesemia
Kazem Anvari,Mehdi Sielanian Toussi,Marjaneh Mirsadraee
Middle East Journal of Cancer , 2010,
Abstract: Background:We assessed the effects of cisplatin-based chemotherapy, magnesium supplementation, probable contributory factors such as cisplatin cumulative dose and dose per cycle on serum magnesium levels. Methods:In this prospective randomized study, serum magnesium levels of 59 newly diagnosed adult patients receiving cisplatin-based chemotherapy were studied.The patients were randomly allocated to receive magnesium supplementation at a dose of 5 g IV per cycle (n=31) or to a control group (n=28). Serum magnesium levels <1.8 mg/dLwere considered to indicate hypomagnesemia. Results:The decrease in mean magnesium levels with continuing chemotherapy courses was significant in both groups with a more prominent decrease in the control group. In courses 4 and 5, mean magnesium levels were significantly higher among those who received magnesium supplementation than in the control group. Thirty patients (50.8%) had at least one incident of hypomagnesemia after beginning chemotherapy. All hypomagnesemia incidents were mild (mean 1.69, range;1.52-1.79 mg/dL). Hypomagnesemia was more frequent in the control group (38.7%vs. 60.7%, P=0.09). Although age and sex had no significant effect on the incidenceof hypomagnesemia, more hypomagnesemia incidents were observed in patients who received cisplatin in a single loading dose than in those who received the drug in divided doses for each cycle (71.4% % vs. 42.9%, P=0.056).Conclusion:Magnesium supplementation at a dose of 5 g per cycle partially compensated for cisplatin- induced magnesium loss. Monitoring magnesium levels and magnesium supplementation is warranted, especially for those undergoingprotracted courses of cisplatin-based chemotherapy. Patients who receive the drug in a single loading dose might be more prone to magnesium loss.
Anorectal Melanoma: A 10-Year Study in the North-East of Iran
Kazem Anvari,Payam Izadpanahi,Bahram Memar
Iranian Journal of Cancer Prevention , 2012,
Abstract: Background: Anorectal melanoma is one of the rare but significant malignancies of the anorectal area. This malignancy currently accounts for 1% of all types of melanoma and less than 1% of all the anorectal area malignancies. Very rare cases of this disease have been reported worldwide.Anorectal melanoma is mostly diagnosed while treating other benign conditions of this area such as hemorrhoids with conventional modalities. Its treatment of choice has always been a controversial issue.Methods: In this study, clinical pathology and outcome of 7 cases with anorectal melanoma referred to Omid Oncology Teaching Hospital during 2001-2011 were assessed.Results: Out of seven cases, 2 patients had been diagnosed with hemorrhoids and undergone surgery and 2 other cases had been referred with the primary diagnosis of lymphoma. Initially, only in 3 cases melanoma was diagnosed in clinico-pathology setting. Three cases of patients had distant metastases to the liver, lungs, omentum and mesentery, while the other 4 patients had advanced local disease. No patient had been diagnosed in the primary stages of the disease. The mean time duration between symptoms onset to diagnosis of disease had been 8 months. The median survival time was 5 months.Conclusion: Rare anorectal melanoma and its similar manifestations to other common anorectal conditions can delay the diagnosis, therefore should be considered as an uncommon differential diagnosis. The disease's outcome is poor and most probably delay in the diagnosis has an important role in the treatment results.
The Effect of Surveillance on the Outcome of Breast Cancer Patients
Kazem Anvari,Azar Fanipakdel,Yasmin Davoudi
Iranian Journal of Cancer Prevention , 2013,
Abstract: Background: The beginning of metastasis poorly affects the prognosis of breast cancer patients. Lung is the most frequent site of visceral metastasis, and the rate of recurrence is 10-30%. We have tried to find out if the routine Chest X Ray (CXR) could play a role for early detection of lung metastasis, during the prognosis of these patients.Methods: The files of the breast cancer patients between 1996 to 2006 (1739 patients) have reviewed. Clinical characteristics of patients with pulmonary metastasis have recorded. Patients, who lacked imaging files or lacked an appropriate follow-up, have excluded. Data have analyzed by SPSS 11.5. The survival analyses have performed by using the Kaplan-Meier method.Results: Fifty-six patients, median age 46, have entered into this retrospective study. Median tumor size was 4cm; median number of Lymphadenopathy (LAP) was 4. The intermediate grade has detected in 74% of patients. All patients have received adjuvant treatment. Median time from cancer diagnosis to pulmonary metastasis was 22 months. Pulmonary metastasis has detected by control CXR in 77.4% and patients' symptoms in 22.6%. Forty eight patients have received chemotherapy in metastatic phase. In 28 patients (50%), other sites of metastasis (bone, liver, and brain) have discovered.The most frequent pattern of lung recurrence was pulmonary nodule (44.6%), followed by pleural effusion (28.6%). Median survival was 27.5; median survival from pulmonary metastasis was 8 m.Conclusion: Early detection of pulmonary metastasis by CXR did not affect patients' endpoints. None of the probable prognostic factors have shown a significant effect on patients' outcome. Despite systemic treatment, survival after metastasis is low.
Expression of Bcl-2 and Bax in Advanced or Metastatic Prostate Carcinoma
Kazem Anvari,Mehdi Seilanian Toussi,Mahmoud Kalantari,Shahram Naseri
Urology Journal , 2012,
Abstract: Purpose: To evaluate the correlation of Bcl-2 and Bax protein expressions with biochemical failure-free survival in patients with advanced or metastatic prostate carcinoma (PCa) undergoing androgen deprivation therapy. Materials and Methods: This retrospective study was performed on patients with locally advanced (≥ T3) or metastatic PCa, who were referred to Omid Hospital between years 2003 and 2007. All subjects had undergone androgen deprivation therapy. Samples were analyzed immunohistochemically for Bax and Bcl-2 expression. The H-score was calculated for each sample based on intensity and percentage of stained cells. H-score > 50 was considered positive. Results: Thirty-seven patients (13 metastatic and 24 locally advanced) were eligible for analysis. Thirty-six (97.3%) samples were positive for Bax and 26 (70.3%) for Bcl-2 expression. The median H-score for Bax and Bcl-2 was 200 (range, 40 to 300) and 85 (range, 0 to 220), respectively. While there was no correlation between Bax expression and Gleason score, high Bcl-2 expression (H-score > 85) was significantly associated with Gleason score > 7 (P = .004). The median time to progression in the advanced and metastatic groups was 22 (range, 10 to 37) months and 16 (range, 9 to 26) months, respectively. High Bcl-2 expression (P = .01) and prostate-specific antigen > 20 ng/mL (P = .01) were significant predictors of lower biochemical progression-free survival. Conclusion: High Bcl-2 expression was associated with higher Gleason scores and lower biochemical-free survival in patients with advanced PCa undergoing androgen deprivation therapy.
Intracranial meningiomas: Prognostic factors and treatment outcome in patients undergoing postoperative radiation therapy
Kazem Anvari,Mehdi Seilanian Toussi,Mohammad Torabi-Nami,Nasrin Roshani,Saeid Rahighi,Sare Hosseini
- , 2016, DOI: 10.4103/2277-9175.182214
Abstract: Meningioma constitutes 20% of the intracranial neoplasms. Followed by surgery as the primary treatment for most patients, radiotherapy becomes indicated in high-grade tumors with incomplete surgical removal. We evaluated the prognostic factors and overall outcome in meningioma patients who underwent radiotherapy
Extending Smooth Cyclic Group Actions on the Poincare Homology Sphere
Nima Anvari
Mathematics , 2014,
Abstract: Let $X_0$ denote a compact, simply-connected smooth $4$-manifold with boundary the Poincar\'e homology $3$-sphere $\Sigma(2,3,5)$ and with even negative definite intersection form $Q_{X_0}=E_8$. We show that free $\mathbb{Z}/p$ actions on $\Sigma(2,3,5)$ do not extend to smooth actions on $X_0$ with isolated fixed points for any prime $p>7$. The approach is to study the equivariant version of the Yang-Mills instanton-one moduli space for $4$-manifolds with cylindrical ends. As an application we show that for $p>7$ a smooth $\mathbb{Z}/p$ action on $\#^8 S^2 \times S^2$ with isolated fixed points does not split along a free action on $\Sigma(2,3,5)$. The results hold for $p=7$ if the action is homologically trivial.
Application of plasma technology in aerospace vehicles: A review
A. Anvari
- , 2019, DOI: 10.5897/JETR2018.0654
Abstract:
Effect of plasma magnet power supplies operating temperatures on the thermal life of space-vehicles
A. Anvari
- , 2019, DOI: 10.5897/JCEMS2019.0334
Abstract:
Objects impact effect on thermal fatigue life of unidirectional T700 Carbon Fiber/Epoxy
Anvari A.
- , 2019, DOI: 10.5897/JCEMS2018.0329
Abstract:
Finding the safest planet for carbon structures in terms of thermal life
A. Anvari
- , 2019, DOI: 10.5897/JCEMS2019.0333
Abstract:
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